The MTHFR (methylenetetrahydrofolate reductase) gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins.
Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the vitamin folate (also called vitamin B9).
Specifically, this enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate.
This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.
What Is a MTHFR Mutation?
According to the Genetics Home Reference Library, MTHFR is a gene that provides the body with instructions for making a certain enzyme called methylenetetrahydrofolate reductase. In fact, “MTHFR” is the shortened name for this enzyme.
There are two main MTHFR mutations that researchers focus on most often. These mutations are often called “polymorphisms” and affect genes referred to as MTHFR C677T and MTHFR A1298C. Mutations can occur on different locations of these genes and be inherited from only one or both parents. Having one mutated allele is associated with increased risk of certain health problems, but having two increases the risk much more.
An MTHFR gene mutation can change the way some people metabolize and convert important nutrients from their diets into active vitamins, minerals and proteins. Genetic mutations can also alter neurotransmitter and hormone levels. In some cases, although not all, changes in how this enzyme works can affect health parameters, including cholesterol levels, brain function, digestion, endocrine functions and more.
MTHFR Mutation Symptoms and Signs
Although researchers still aren’t entirely sure which diseases and disorders an MTHRF mutation might contribute to most, evidence exists that the following health problems are tied to one of two primary forms of genetic MTHFR mutation:
- Autism and other childhood learning developmental problems
- Down syndrome
- Depression and anxiety
- Spina bifida
- Bipolar disorder
- Autoimmune disorders and thyroid disorders
- Addictions (alcohol and drug dependence for example)
- Chronic pain disorders
- Heart problems, including low HDL “good” cholesterol levels and high homocysteine levels
- Hormonal problems and fertility problems, including miscarriages and PCOS
- Pulmonary embolisms
- Chronic fatigue syndrome
- Parkinson’s disease, other tremor disorders and Alzheimer’s disease
- Digestive problems, including irritable bowel syndrome
- Problems during pregnancy, including preeclampsia and postpartum depression
The severity and type of symptoms that someone experiences depends on the variant of the mutation the person has, along with much how the ability to carry out methylation and make MTHFR enzymes is impacted. Some people produce up to 70 percent to 90 percent fewer enzymes than those without MTHFR mutations. Other experience much less drastic drops in enzyme levels, around 10 percent to 30 percent.
Source: Dr. Axe
KOSA Acupuncture’s Understanding & Treatment
Most of the health problems are the indications (whether single or multiple) of unhealthy liver.
Thus, treating the liver properly would alleviate the problems.
The DNA is supposed to keep changing.
Learn more: DNA keeps changing?
Based on Ascetic Saahm’s formula #1, fostering large intestine, subdue ST41, BL60, KI2 and LR2.
If the patient had overlapping conditions they need to be treated at once and of course, the treatment needs to be changed accordingly.